Association between serum insulin-like growth factor-1 and bone mineral density in patients with type 2 diabetes.

ABSTRACT:

Background

Secondary osteoporosis is associated with type 2 diabetes mellitus (T2DM), and there is conflicting evidence regarding the relationship between insulin-like growth factor-1 (IGF-1) and bone mineral density (BMD) in different populations. The objective of this study was to investigate the relationship between serum IGF-1 levels and BMD in patients with T2DM.

Method

A retrospective cross-sectional study was performed on a cohort of 363 patients with T2DM, comprising men aged over 50 and women who are postmenopausal. Those with no significant medical history or medication affecting BMD or IGF-1 were considered. Data analyzed included IGF-1 levels, markers of bone metabolism, and measurements of BMD. To account for age and gender variations, we calculated IGF-1 standa

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11466823 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature