Mendelian randomization suggests causal correlations between inflammatory cytokines and immune cells with mastitis.

ABSTRACT:

Objectives

Previous studies have reported that immunoinflammatory responses have associations with mastitis. Here, we aimed to further figure out whether circulating inflammatory cytokines and immune cells causally impact mastitis liability.

Methods

The two-sample Mendelian randomization made use of genetic variances of 91 inflammatory cytokines from a large publicly available genome-wide association study (GWAS) containing 14,824 participants, 731 immunophenotypes data from 3,757 individuals as exposures separately, and mastitis from a GWAS summary (1880 cases and 211699 controls of European ancestry) as outcome. The primary analysis applied the inverse-variance weighted (IVW) method to estimate causal influences, with MR-Egger, weighted median, weighted mode and simple mod

SUBMITTER: Chen J 

PROVIDER: S-EPMC11466835 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature