Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians.

ABSTRACT: Most genetic variants associated with adult height have been identified through large genome-wide association studies (GWASs) in European-ancestry cohorts. However, it is unclear how these variants influence linear growth during adolescence. This study uses anthropometric and genotypic data from a longitudinal study conducted in an American Indian community in Arizona between 1965-2007. Growth parameters (i.e. height, velocity, and timing of growth spurt) were derived from the Preece-Baines growth model, a parametric growth curve fitted to longitudinal height data, in 787 participants with height measurements spanning the whole period of growth. Heritability estimates suggested that genetic factors could explain 25% to 71% of the variance of pubertal growth traits. We performed a GWAS of g

SUBMITTER: Ramirez-Luzuriaga MJ 

PROVIDER: S-EPMC11466845 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature