Environmental and occupational exposures and prognosis in patients with non-muscle-invasive bladder cancer in the Be-Well Study.

ABSTRACT: Bladder cancer is primarily diagnosed as non-muscle-invasive bladder cancer (NMIBC), with high recurrence and progression rates. Environmental and occupational exposures to carcinogens are well-known risk factors for developing bladder cancer, yet their effects on prognosis remain unknown. In the Be-Well Study, a population-based prospective cohort study of 1472 Kaiser Permanente patients newly diagnosed with NMIBC in California from 2015 to 2019, we examined history of environmental and occupational exposures in relation to tumor stage and grade at initial diagnosis by multivariable logistic regression, and subsequent recurrence and progression by Cox proportional hazards regression. Exposure to environmental and occupational carcinogens was significantly associated with increased risk of

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11466861 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature