Impaired brain glucose metabolism in glucagon-like peptide-1 receptor knockout mice.

ABSTRACT:

Background

Quantitative mapping of the brain's metabolism is a critical tool in studying and diagnosing many conditions, from obesity to neurodegenerative diseases. In particular, noninvasive approaches are urgently required. Recently, there have been promising drug development approaches for the treatment of disorders related to glucose metabolism in the brain and, therefore, against obesity-associated diseases. One of the most important drug targets to emerge has been the Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R). GLP and GLP-1R play an important role in regulating blood sugar and maintaining energy homeostasis. However, the macroscopic effects on brain metabolism and function due to the presence of GLP-1R are unclear.

Methods

To explore the physiological r

SUBMITTER: Li H 

PROVIDER: S-EPMC11466955 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature