Association between coffee consumption and metabolic syndrome: A cross-sectional and Mendelian randomization study.

ABSTRACT:

Background

This study investigates the associations between coffee consumption and metabolic syndrome and its components, as well as the effect of milk, sugar, and artificial sweeteners on these associations.

Methods

A cross-sectional analysis was conducted with 351805 UK Biobank participants. Coffee consumption data were collected via food frequency questionnaires and 24-h recall. Metabolic syndrome was identified through blood biochemistry and self-reported medication use. Odds ratios were calculated using multivariable logistic regression, and results were verified with two-sample Mendelian randomization.

Results

Consuming up to two cups of coffee per day was inversely associated with metabolic syndrome (1 cup/day: odds ratio [OR]: 0.88, 95% confidence interval [CI

SUBMITTER: Wong THT 

PROVIDER: S-EPMC11467012 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature