Reduction of myeloid-derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment.

ABSTRACT:

Background

In a previously reported Phase I trial, we observed therapy-associated declines in circulating myeloid-derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets in prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.

Methods

We performed bidirectional translational research to examine the immunomodulatory effects of WBM consumption in both syngeneic murine PCa models and patients with PCa participating in an ongoing randomised Phase II trial (NCT04519879).

Results

In murine models, WBM treatment significantly suppressed tumour growth with a reduction in both the number and function of MDSCs, which in turn promoted antitumour immune respons

SUBMITTER: Wang X 

PROVIDER: S-EPMC11467013 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature