Adolescent sleep patterns, genetic predisposition, and risk of multiple sclerosis.

ABSTRACT:

Study objectives

Shift work, insufficient sleep, and poor sleep quality at young age have been associated with increased risk of multiple sclerosis (MS). This study aimed to investigate the potential interaction between aspects of inadequate sleep (short sleep, phase shift, and poor sleep quality) during adolescence and HLA-DRB1*15:01 in relation to MS risk.

Methods

We used a Swedish population-based case-control study (1253 cases and 1766 controls). Participants with different sleep patterns during adolescence and HLA-DRB1*15:01 status were compared regarding MS risk by calculating odds ratios with 95% confidence intervals (CI) using logistic regression models. Additive interaction between aspects of inadequate sleep and HLA-DRB1*15:01 status was assessed by calculating the

SUBMITTER: Johansson E 

PROVIDER: S-EPMC11467049 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature