The interplay between insomnia symptoms and Alzheimer's disease across three main brain networks.

ABSTRACT:

Study objectives

Insomnia symptoms are prevalent along the trajectory of Alzheimer's disease (AD), but the neurobiological underpinning of their interaction is poorly understood. Here, we assessed structural and functional brain measures within and between the default mode network (DMN), salience network, and central executive network (CEN).

Methods

We selected 320 participants from the ADNI database and divided them by their diagnosis: cognitively normal (CN), Mild Cognitive Impairment (MCI), and AD, with and without self-reported insomnia symptoms. We measured the gray matter volume (GMV), structural covariance (SC), degrees centrality (DC), and functional connectivity (FC), testing the effect and interaction of insomnia symptoms and diagnosis on each index. Subsequently,

SUBMITTER: Elberse JD 

PROVIDER: S-EPMC11467060 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature