Observational pilot study of multi-wavelength wearable light dosimetry for erythropoietic protoporphyria.

ABSTRACT:

Background

Erythropoietic protoporphyria (EPP) causes painful light sensitivity, limiting quality of life. Our objective was to develop and validate a wearable light exposure device and correlate measurements with light sensitivity in EPP to predict and prevent symptoms.

Methods

A wearable light dosimeter was developed to capture light doses of UVA, blue, and red wavelengths. A prospective observational pilot study was performed in which five EPP patients wore two light dosimeters for 3 weeks, one as a watch, and one as a shirt clip.

Results

Standard deviation (SD) increases from the mean in the daily blue light dose increased the odds ratio (OR) for symptom risk more than the self-reported outdoor time (OR 2.76 vs. 2.38) or other wavelengths, and a one SD increase fr

SUBMITTER: Dickey AK 

PROVIDER: S-EPMC11467130 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature