Real-Life Effectiveness of iGlarLixi (Insulin Glargine 100 U/ml and Lixisenatide) in People with Type 2 Diabetes (T2D) According to Baseline HbA1c and BMI.

ABSTRACT:

Introduction

This study aimed to evaluate the effect of baseline body mass index (BMI) and glycated hemoglobin (HbA1c) on the effectiveness and safety of initiating iGlarLixi (insulin glargine 100 U/ml and lixisenatide) in people with type 2 diabetes (T2D) in routine clinical practice.

Methods

We pooled patient-level data from 1406 people with inadequately controlled T2D, initiating a 24-week iGlarLixi treatment. Analysis sets were based on baseline BMI and HbA1c. In the BMI set, 894 (64%) people had a BMI ≥ 30 kg/m² and 510 (36%) a BMI < 30 kg/m²; in the HbA1c set, 615 (44%) people had an HbA1c  >9%, 491 (35%) between 8 and 9%, and 298 (21%) < 8%.

Results

After initiating iGlarLixi, HbA1c decreased in all participants, with the greatest least-sq

SUBMITTER: Kis JT 

PROVIDER: S-EPMC11467142 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature