Gut Microbiota in Primary Osteoporosis: a Systematic Review.

ABSTRACT: The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencing methodologies. Notably, the taxonomic profiles exhibited pronounced heterogeneity across reviewed studies. A combined analysis of mechanistical studies screened out potential targets for osteoporosis prevention and treatment. We appraised the limitations in previous studies, and proposed suggestions for optimizing sequencing techniques and experimental designs. Larger-size longitudinal cohorts based on multi-omics and extended phenotypes are recommended to comprehensively characterize the involvement of GM in the pathogenesis of osteoporosis.

Supplementary information

The onl

SUBMITTER: Ji J 

PROVIDER: S-EPMC11467150 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature