New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population.

ABSTRACT: Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative abundance of 881 gut metagenomic species (> 5% prevalence) and 103 gut metabolic modules (GMMs). Altogether, 97 associations of 26 medications with 40 species and of four medications with five GMMs were observed (false discovery rate < 5%). Several earlier findings were replicated like the positive associations of proton pump inhibitors (PPIs) with numerous oral species, and those of metformin wit

SUBMITTER: Larsson A 

PROVIDER: S-EPMC11467196 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature