Dysregulated GLUT1 results in the pathogenesis of preeclampsia by impairing the function of trophoblast cells.

ABSTRACT: Preeclampsia (PE) is a common placental-origin complication of pregnancy and a major cause of morbidity and mortality among pregnant women and fetuses. However, its pathogenesis has not been elucidated. Effective strategies for prevention, screening, and treatment are still lacking. Studies have indicated that dysfunction of placental trophoblast cells, such as impaired syncytialization, proliferation, and epithelial-mesenchymal transition processes, plays a crucial role in the development of PE. Glucose transporter 1 (GLUT1) is a key protein regulating glucose transport in placental tissues. However, the effect of GLUT1 on the function of trophoblast cells in PE is not well understood. In this study, we found that GLUT1 expression is reduced in PE placental tissues. GLUT1 promotes the syn

SUBMITTER: Pei J 

PROVIDER: S-EPMC11467397 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature