Dysbiotic signatures and diagnostic potential of gut microbial markers for inflammatory bowel disease in Korean population.

ABSTRACT: Fecal samples were collected from 640 individuals in Korea, including 523 patients with IBD (223 with Crohn's disease [CD] and 300 with ulcerative colitis [UC]) and 117 healthy controls. The samples were subjected to cross-sectional gut metagenomic analysis using 16 S rRNA sequencing and bioinformatics analysis. Patients with IBD, particularly those with CD, exhibited significantly lower alpha diversities than the healthy subjects. Differential abundance analysis revealed dysbiotic signatures, characterized by an expansion of the genus Escherichia-Shigella in patients with CD. Functional annotations showed that functional pathways related to bacterial pathogenesis and production of hydrogen sulfide (H₂S) were strongly upregulated in patients with CD. A dysbiosis score, calculate

SUBMITTER: Kim HS 

PROVIDER: S-EPMC11467411 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature