The effect of non-steroidal anti-inflammatory drugs on postoperative delirium: a meta-analysis.

ABSTRACT:

Background

Neuroinflammation is postulated as a potential mechanism underlying postoperative delirium. This study aimed to investigate the impact of non-steroidal anti-inflammatory drug (NSAID) use on postoperative delirium.

Methods

We conducted a literature search in electronic databases, including PubMed, EMBASE, CENTRAL, and Web of Science, to identify eligible randomized controlled studies. The primary outcome was the incidence of postoperative delirium, and the secondary outcomes included pain scores and the amounts of opioid used at 24 h postoperatively. We estimated the effect size through calculating the odds ratios (ORs) or mean differences (MDs) with 95% CIs, as appropriate.

Results

In the analysis of eight studies involving 1,238 participants, the incidence

SUBMITTER: Kim SY 

PROVIDER: S-EPMC11467501 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature