Platelet interaction and performance of antibacterial bioinspired nanostructures passivated with human plasma.

ABSTRACT: The ever-increasing ageing of the world population is demanding superior orthopedic devices. Issues such as implant infection, poor osseointegration, or chronic inflammation remain problematic to the lifespan and long-term efficacy of implants. Fabrication of materials with bioinspired nanostructures is one emerging antibacterial strategy to prevent implant infection, however their interactions with blood components, and whether they retain their bactericidal properties in an environment displaying a complex protein corona, remains largely unexplored. In the present study, titanium alloy, commercially pure and plasma-sprayed titania were hydrothermally etched, passivated with human native plasma to develop a protein corona, and then incubated with either Staphylococcus aureus, Ps

SUBMITTER: Burzava ALS 

PROVIDER: S-EPMC11467677 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature