White matter variations in congenital adrenal hyperplasia: possible implications for glucocorticoid treatment.

ABSTRACT: Congenital adrenal hyperplasia has been reported to manifest with white matter aberrations. However, many previous studies included only small samples, restricted their analyses to females, lacked a control group and/or did not correct for brain size. Here, we examined the largest sample to date, comprising 53 male and female participants with congenital adrenal hyperplasia, who were matched with 53 male and female controls in terms of sex, age, education, and verbal intelligence. The four groups were compared with respect to their total white matter as well as white matter hyperintensities while applying brain size corrections. For both measures, total white matter and white matter hyperintensities, there were no significant sex differences or group-by-sex interactions. However, individua

SUBMITTER: Luders E 

PROVIDER: S-EPMC11467690 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature