Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis.

ABSTRACT:

Background

Epidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to be related to skin inflammation in AD.

Objectives

This study aimed to explore the effects of PM on AD and investigate the role of PXR in PM-exposed AD.

Methods

In vivo and in vitro AD-like models were employed, using BALB/c mice, immortalized human keratinocytes (HaCaT), and mouse CD4 ⁺ T cells.

Results

Topical application of PM significantly increased dermatitis score and skin thickness in AD-like mice. PM treatment increased the mRNA and protein levels of type 17 infla

SUBMITTER: Lee JS 

PROVIDER: S-EPMC11467722 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature