Personal history of irradiation and risk of breast cancer: A Mendelian randomisation study.

ABSTRACT:

Background

Studies on the relationship between personal history of irradiation and breast cancer have been reported for a long time. Still, epidemiological studies have not been conclusive, and the causal relationship is unclear. To address this issue, we employed Mendelian randomisation (MR) analysis to examine the association between individual radiation exposure history and breast cancer.

Methods

We used a series of quality control methods to select single nucleotide polymorphism (SNP) closely related to exposure. Meanwhile, several analysis methods were used to analyse the sample data to make the conclusion more reliable. To evaluate the horizontal pleiotropy, heterogeneity and stability of SNPs for breast cancer, the MR-Egger intercept test, Cochran's Q test and 'leave

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11467774 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature