Impact of heteroresistance on treatment outcomes of people with drug-resistant TB.

ABSTRACT:

Background

Poor treatment outcomes among people with drug-resistant TB (DR-TB) are a major concern. Heteroresistance (presence of susceptible and resistant Mycobacterium tuberculosis in the same sample) has been identified in some people with TB, but its impact on treatment outcomes is unknown.

Methods

We used targeted deep sequencing to identify mutations associated with DR-TB and heteroresistance in culture samples of 624 people with DR-TB. We evaluated the association between heteroresistance and time to unfavorable treatment outcome using Cox proportional hazards regression.

Results

The proportion of drug-resistant isolates with a known mutation conferring resistance was lower for streptomycin (45.2%) and second-line injectables (79.1%) than for fluoroquino

SUBMITTER: Crowder R 

PROVIDER: S-EPMC11467852 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature