Comprehensive analysis of prognostic and immunological role of basement membrane-related genes in soft tissue sarcoma.

ABSTRACT:

Background

Soft tissue sarcoma (STS) represents highly multifarious malignant tumors that often occur in adolescents and have a poor prognosis. The basement membrane, as an ancient cellular matrix, was recently proven to play a vital role in developing abundant tumors. The relationship between basement membrane-related genes and STS remains unknown.

Methods

Consensus clustering was employed to identify subgroups related to differentially expressed basement membrane-related genes. Cox and least absolute shrinkage and selection operator regression analyses were utilized to construct this novel signature. Then, we established a nomogram and calibration curve, including the risk score and available clinical characteristics. Finally, we carried out functional enrichment analysis

SUBMITTER: Nie GH 

PROVIDER: S-EPMC11467964 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature