Higher serum phosphate within the normal range is associated with the development of calcified aortic valve disease.

ABSTRACT:

Background

Despite the essential role of ectopic osteogenic calcium-phosphate metabolism in the development of calcific aortic valve disease (CAVD), the implications of high serum phosphate levels in CAVD development are not fully understood.

Methods

Asymptomatic individuals who underwent health screening using serial cardiac computed tomography (CT) and echocardiography were selected from a multicenter registry. CAVD was identified and quantified on CT images using the aortic valve calcification (AVC) score. The associations between initial serum phosphate levels and the presence of baseline CAVD, development of new CAVD, and the AVC score progression rate were investigated using multivariable regression models.

Results

A total of 736 individuals were selected for an

SUBMITTER: Kim KA 

PROVIDER: S-EPMC11467965 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature