Optimizing the combination of chemotherapeutic drugs along with radiotherapy for extranodal NK/T-cell lymphoma.

ABSTRACT:

Background

Extranodal natural killer/T-cell lymphoma (ENKTCL) has a unique treatment principle. However, the optimal combination of drugs along with radiotherapy (RT) is unknown.

Design

Retrospective cohort study.

Objectives

We screened multiple drug combinations to identify the most efficacious therapeutic combinations.

Methods

We reviewed 3105 patients who received 40 chemotherapy regimens with different combinations of 9 drug classes and/or RT. Least absolute shrinkage and selection operator and multivariable Cox regression analyses were used to screen efficacious single drugs and identify optimal combinations for overall survival (OS). Inverse probability of treatment weighting (IPTW) and multivariable analyses were used to compare survival between treatmen

SUBMITTER: Luo F 

PROVIDER: S-EPMC11468003 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature