MiR-210 is essential to retinal homeostasis in fruit flies and mice.

ABSTRACT:

Background

miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseases and cancer. Recently, new roles of this microRNA are emerging in the context of eye and visual system homeostasis. Recent studies in Drosophila melanogaster unveiled that the absence of miR-210 leads to a progressive retinal degeneration characterized by the accumulation of lipid droplets and disruptions in lipid metabolism. However, the possible conservation of miR-210 knock-out effect in the mammalian retina has yet to be explored.

Results

We further investigated lipid anabolism and catabolism in miR-210 knock-out (KO) flies, uncovering significant alter

SUBMITTER: Colaianni D 

PROVIDER: S-EPMC11468086 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature