Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis.

ABSTRACT:

Background

To investigate the association of vitamin D receptor (VDR) gene polymorphism with caries risk in children(< 18 years).

Methods

The electronic databases PubMed, Cochrane, EMBASE, Web of Science, CNKI, Cqvip, and Wanfang were searched for observational studies on the relationship between VDR single nucleotide polymorphism(SNP) and caries, including cohort, case-control, and cross-sectional studies. Quality assessment of selected studies was conducted using the Newcastle Ottawa scale. Odds ratios (OR) with 95% confidence intervals (CI) values for associations of individual VDR SNP with dental caries were calculated based on four genetic models: allelic, recessive, dominant, and over-dominant.

Results

Of 79 studies considered, 10 (nine case-control and one cros

SUBMITTER: Qin X 

PROVIDER: S-EPMC11468088 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature