Effects of single and combined urinary polycyclic aromatic hydrocarbon effects on lung function in the U.S. adult population.

ABSTRACT:

Background

The impact of polycyclic aromatic hydrocarbons (PAHs) on lung function has garnered attention, but studies mostly focus on individual effect. This study investigates urinary PAH metabolites as biomarkers of exposure and assesses the relationships between single and combined exposures to nine urinary PAH metabolites and lung function in adults.

Methods

Data from 4040 adults in the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were analyzed. Weighted generalized linear models estimated the effects of individual PAH metabolites on lung function. Additionally, weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) were employed to evaluate the combined impacts of multiple PAH metabol

SUBMITTER: Fang P 

PROVIDER: S-EPMC11468208 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature