The distinct functional brain network and its association with psychotic symptom severity in men with methamphetamine-associated psychosis.

ABSTRACT:

Background

Individuals using methamphetamine (METH) may experience psychosis, which usually requires aggressive treatment. Studies of the neural correlates of METH-associated psychosis (MAP) have focused predominantly on the default mode network (DMN) and cognitive control networks. We hypothesize that METH use alters global functional connections in resting-state brain networks and that certain cross-network connections could be associated with psychosis.

Methods

We recruited 24 healthy controls (CRL) and 54 men with METH use disorder (MUD) who were then divided into 25 without psychosis (MNP) and 29 with MAP. Psychotic symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS), evaluating (1) large-scale alterations in regional-wise resting-state

SUBMITTER: Hwang ZA 

PROVIDER: S-EPMC11468263 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature