Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies.

ABSTRACT:

Background

The associations of different obesity and metabolic phenotypes during midlife with the risk of incident dementia remain unclear. This study aimed to investigate the associations between metabolic heterogeneity of obesity and long-term risk of dementia.

Methods

We conducted prospective analyses from three cohorts, including the UK Biobank (UKB), Atherosclerosis Risk in Communities (ARIC) study, and Framingham Offspring Study (FOS). Eligible participants were those aged 45-65 years with valid assessments of body mass index (BMI) and metabolic status at the study baseline. Obesity was defined as a BMI of ≥ 30.0 kg/m², while metabolic abnormality was defined as meeting ≥ 2 of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III

SUBMITTER: Ding Y 

PROVIDER: S-EPMC11468300 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature