Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation.

ABSTRACT: An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT-PU (≈27 mF cm^-2 ) ensures a saf

SUBMITTER: Terutsuki D 

PROVIDER: S-EPMC11468388 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature