Microtissue-Based Bioink as a Chondrocyte Microshelter for DLP Bioprinting.

ABSTRACT: Bioprinting specific tissues with robust viability is a great challenge, requiring a delicate balance between a densely cellular distribution and hydrogel network crosslinking density. Microtissues composed of tissue-specific mesenchymal stem cells and extra cellular matrix (ECM) particles provide an alternative scheme for realizing biomimetic cell density and microenvironment. Nevertheless, due to their instability during manufacturing, scarce efforts have been made to date to assemble them using rapid prototyping methods. Here, a novel microtissue bioink with good printability and cellular viability maintenance for digital light processing (DLP) bioprinting is introduced. Generally, the microtissue bioink is prepared by crosslinking acellular matrix microparticles and GelMA hydrogel with

SUBMITTER: Xie X 

PROVIDER: S-EPMC11468467 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature