Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity.

ABSTRACT:

Background

Src family kinases (SFKs) contribute to migraine pathogenesis, yet its role in regulating photophobia behaviour, one of the most common forms of migraine, remains unknown. Here, we addressed whether SFKs antagonism alleviates photophobia behavior and explored the underlying mechanism involving hypothalamus and trigeminal ganglion activity, as measured by the alteration of neuropeptide levels and transcriptome respectively.

Methods

A rapid-onset and injury-free mouse model of photophobia was developed following intranasal injection of the TRPA1 activator, umbellulone. The role of SFKs antagonism on light aversion was assessed by the total time the mouse stays in the light and transition times between the dark and light compartments. To gain insight to the preventiv

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11468534 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature