Ultrathin 2D Titanium Carbide MXene (Ti₃ C₂ T_x ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.

ABSTRACT: Periodontal defect regeneration in severe periodontitis relies on the differentiation and proliferation of periodontal ligament cells (PDLCs). Recently, an emerging 2D nanomaterial, MXene (Ti₃ C₂ T_x ), has gained more and more attention due to the extensive antibacterial and anticancer activity, while its potential biomedical application on tissue regeneration remains unclear. Through a combination of experimental and multiscale simulation schemes, Ti₃ C₂ T_x has exhibited satisfactory biocompatibility and induced distinguish osteogenic differentiation of human PDLCs (hPDLCs), with upregulated osteogenesis-related genes. Ti₃ C₂ T_x manages to activate the Wnt/β-catenin signaling pathway by enha

SUBMITTER: Cui D 

PROVIDER: S-EPMC11468541 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature