Association between gut microbiota and diabetic nephropathy: a two-sample mendelian randomization study.

ABSTRACT:

Background

Observational studies have demonstrated the alterations of gut microbiota composition in diabetic nephropathy (DN), however, the correlation between gut microbiota and DN remains unclear.

Methods

A two-sample Mendelian randomization (MR) analysis was designed to estimate the association between gut microbiota and DN. The summary statistics of gut microbiota from phylum level to genus level were obtained from a large-scale, genome-wide association study involving 18,340 individuals, and the data at the species level was derived from the study of TwinsUK Registry, including 1126 twin pairs. The summary statistics of DN were originated from the latest release data of FinnGen (R7, 299623 participants). The MR estimation was calculated using inverse variance weighted,

SUBMITTER: Han S 

PROVIDER: S-EPMC11468553 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature