Pharmacokinetics of Intramuscularly Administered Thermoresponsive Polymers.

ABSTRACT: Aqueous solutions of some polymers exhibit a lower critical solution temperature (LCST); that is, they form phase-separated aggregates when heated above a threshold temperature. Such polymers found many promising (bio)medical applications, including in situ thermogelling with controlled drug release, polymer-supported radiotherapy (brachytherapy), immunotherapy, and wound dressing, among others. Yet, despite the extensive research on medicinal applications of thermoresponsive polymers, their biodistribution and fate after administration remained unknown. Thus, herein, they studied the pharmacokinetics of four different thermoresponsive polyacrylamides after intramuscular administration in mice. In vivo, these thermoresponsive polymers formed depots that subsequently dissolved with a two-ph

SUBMITTER: Groborz O 

PROVIDER: S-EPMC11468617 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature