Liquid-Liquid Phase-Separated Systems from Reversible Gel-Sol Transition of Protein Microgels.

ABSTRACT: Liquid-liquid phase-separated biomolecular systems are increasingly recognized as key components in the intracellular milieu where they provide spatial organization to the cytoplasm and the nucleoplasm. The widespread use of phase-separated systems by nature has given rise to the inspiration of engineering such functional systems in the laboratory. In particular, reversible gelation of liquid-liquid phase-separated systems could confer functional advantages to the generation of new soft materials. Such gelation processes of biomolecular condensates have been extensively studied due to their links with disease. However, the inverse process, the gel-sol transition, has been less explored. Here, a thermoresponsive gel-sol transition of an extracellular protein in microgel form is explored, re

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11468722 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature