Infrared-Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia.

ABSTRACT: Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. However, MNPs fail to provide real-time thermal feedback with the risk of unwanted overheating and impeding on-the-fly adjustment of the therapeutic parameters. Localization of MNPs within a tissue in an accurate, rapid, and cost-effective way represents another challenge for increasing the efficacy of MHT. In this work, MNPs are combined with state-of-the-art infrared luminescent nanothermometers

SUBMITTER: Ximendes E 

PROVIDER: S-EPMC11468761 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature