Photomodulated Extrusion as a Localized Endovascular Hydrogel Deposition Method.

ABSTRACT: Minimally invasive endovascular embolization is used to treat a wide range of diseases in neurology, oncology, and trauma where the vascular morphologies and corresponding hemodynamics vary greatly. Current techniques based on metallic coils, flow diverters, liquid embolics, and suspended microspheres are limited in their ability to address a wide variety of vasculature and can be plagued by complications including distal migration, compaction, and inappropriate vascular remodeling. Further, these endovascular devices currently offer limited therapeutic functions beyond flow control such as drug delivery. Herein, a novel in situ microcatheter-based photomodulated extrusion approach capable of dynamically tuning the physical and morphological properties of injectable hydrogels, optimizing f

SUBMITTER: Dobashi Y 

PROVIDER: S-EPMC11468792 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature