Calcium Phosphate-Coated and Strontium-Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation.

ABSTRACT: Ceramic (nano)materials are promising materials for bone regeneration applications. The addition of bioinorganics such as strontium (Sr) and zinc (Zn) is a popular approach to further improve their biological performance. However, control over ion delivery is important to prevent off-target effects. Mesoporous silica nanoparticles (MSNs) are popular nanomaterials that can be designed to incorporate and controllably deliver multiple ions to steer specific regenerative processes. In this work, MSNs loaded with Sr (MSN_Sr ) and surface coated with a pH-sensitive calcium phosphate (MSN_Sr -CaP) or calcium phosphate zinc layer (MSN_Sr -CaZnP) are developed. The ability of the MSNs to promote osteogenesis in human mesenchymal stromal cells (hMSCs) under basic cell c

SUBMITTER: Sutthavas P 

PROVIDER: S-EPMC11468810 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature