Biomechanics, Energetics, and Structural Basis of Rupture of Fibrin Networks.

ABSTRACT: Fibrin provides the main structural integrity and mechanical strength to blood clots. Failure of fibrin clots can result in life-threating complications, such as stroke or pulmonary embolism. The dependence of rupture resistance of fibrin networks (uncracked and cracked) on fibrin(ogen) concentrations in the (patho)physiological 1-5 g L^-1 range is explored by performing the ultrastructural studies and theoretical analysis of the experimental stress-strain profiles available from mechanical tensile loading assays. Fibrin fibers in the uncracked network stretched evenly, whereas, in the cracked network, fibers around the crack tip showed greater deformation. Unlike fibrin fibers in cracked networks formed at the lower 1-2.7 g L^-1 fibrinogen concentrations, fibers formed

SUBMITTER: Ramanujam RK 

PROVIDER: S-EPMC11468835 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature