Printed Silk Microelectrode Arrays for Electrophysiological Recording and Controlled Drug Delivery.

ABSTRACT: The use of soft and flexible bioelectronic interfaces can enhance the quality for recording cells' electrical activity by ensuring a continuous and intimate contact with the smooth, curving surfaces found in the physiological environment. This work develops soft microelectrode arrays (MEAs) made of silk fibroin (SF) films for recording interfaces that can also serve as a drug delivery system. Inkjet printing is used as a tool to deposit the substrate, conductive electrode, and insulator, as well as a drug-delivery nanocomposite film. This approach is highly versatile, as shown in the fabrication of carbon microelectrodes, sandwiched between a silk substrate and a silk insulator. The technique permits the development of thin-film devices that can be employed for in vitro extracellular recor

SUBMITTER: Adly N 

PROVIDER: S-EPMC11468847 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature