Manganese Porphyrin-Containing Polymeric Micelles: A Novel Approach for Intracellular Catalytic Formation of Per/Polysulfide Species from a Hydrogen Sulfide Donor.

ABSTRACT: Per/polysulfide species that are generated from endogenously produced hydrogen sulfide have critical regulatory roles in a wide range of cellular processes. However, the lack of delivery systems that enable controlled and sustained release of these unstable species in biological systems hinders the advancement of sulfide biology research, as well as the translation of knowledge to therapeutic applications. Here, a novel approach is developed to generate per/polysulfide species in cells by combining an H₂ S donor and manganese porphyrin-containing polymeric micelles (MnPMCs) that catalyze oxidization of H₂ S to per/polysulfide species. MnPMCs serve as a catalyst for H₂ S oxidation in aerobic phosphate buffer. HPLC-MS/MS analysis reveals that H₂ S

SUBMITTER: Young K 

PROVIDER: S-EPMC11468854 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature