Brain mechanisms of rumination and negative self-referential processing in adolescent depression.

ABSTRACT:

Background

Depression is linked to cognitive biases towards more negative and less positive self-relevant information. Rumination, perseverative negative thinking about the past and the self, may contribute to these biases.

Methods

159 adolescents (12-18 years), with a range of depression symptoms, completed the SRET during fMRI. Multiple regressions tested associations between conventional self-report and ecological momentary assessment (EMA) measured rumination, and neural and behavioral responses during a self-referent encoding task (SRET).

Results

Higher rumination (conventional self-report and EMA) was associated with more negative and fewer positive words endorsed and recalled. Higher self-reported (but not EMA) rumination was associated with higher accuracy in

SUBMITTER: Murray L 

PROVIDER: S-EPMC11468901 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature