IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections.

ABSTRACT: Neutrophil subsets endowed with regulatory/suppressive properties are widely regarded as deleterious immune cells that can jeopardize antitumoral response and/or antimicrobial resistance. Here, we describe a sizeable fraction of neutrophils characterized by the expression of programmed death-ligand 1 (PD-L1) in biological fluids of humans and mice with severe viral respiratory infections (VRI). Biological and transcriptomic approaches indicated that VRI-driven PD-L1⁺ neutrophils are endowed with potent regulatory functions and reduced classical antimicrobial properties, as compared to their PD-L1^- counterpart. VRI-induced regulatory PD-L1⁺ neutrophils were generated remotely in the bone marrow in an IFN-γ-dependent manner and were quickly mobilized into the

SUBMITTER: Creusat F 

PROVIDER: S-EPMC11468905 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature