Supramolecular Heterodimer Peptides Assembly for Nanoparticles Functionalization.

ABSTRACT: Nanoparticle (NP) surface functionalization with proteins, including monoclonal antibodies (mAbs), mAb fragments, and various peptides, has emerged as a promising strategy to enhance tumor targeting specificity and immune cell interaction. However, these methods often rely on complex chemistry and suffer from batch-dependent outcomes, primarily due to limited control over the protein orientation and quantity on NP surfaces. To address these challenges, a novel approach based on the supramolecular assembly of two peptides is presented to create a heterotetramer displaying V_HHs on NP surfaces. This approach effectively targets both tumor-associated antigens (TAAs) and immune cell-associated antigens. In vitro experiments showcase its versatility, as various NP types are biofunctio

SUBMITTER: Mathieu C 

PROVIDER: S-EPMC11468928 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature