Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics.

ABSTRACT: Personalized antibiotherapy ensures that the antibiotic concentration remains in the optimal therapeutic window to maximize efficacy, minimize side effects, and avoid the emergence of drug resistance due to insufficient dosing. However, such individualized schemes need frequent sampling to tailor the blood antibiotic concentrations. To optimally integrate therapeutic drug monitoring (TDM) into the clinical workflow, antibiotic levels can either be measured in blood using point-of-care testing (POCT), or can rely on noninvasive sampling. Here, a versatile biosensor with an antibody-free assay for on-site TDM is presented. The platform is evaluated with an animal study, where antibiotic concentrations are quantified in different matrices including whole blood, plasma, urine, saliva, and exha

SUBMITTER: Ates HC 

PROVIDER: S-EPMC11468941 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature