Tissue Engineering with Mechanically Induced Solid-Fluid Transitions.

ABSTRACT: Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, such as the kidney tubules and the complex branching structures found in the lung. The maintenance of epithelial morphogenesis and homeostasis is controlled by their remarkable mechanics-epithelia can become elastic, plastic, and viscous by actively remodeling cell-cell junctions and modulating the distribution of local stresses. Microfabrication, finite element modelling, light-sheet microscopy, and robotic micromanipulation are used to show that collagen gels covered with an epithelial skin serve as shape-programmable soft matter. The proc

SUBMITTER: Mailand E 

PROVIDER: S-EPMC11468955 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature