High-Scale 3D-Bioprinting Platform for the Automated Production of Vascularized Organs-on-a-Chip.

ABSTRACT: 3D bioprinting possesses the potential to revolutionize contemporary methodologies for fabricating tissue models employed in pharmaceutical research and experimental investigations. This is enhanced by combining bioprinting with advanced organs-on-a-chip (OOCs), which includes a complex arrangement of multiple cell types representing organ-specific cells, connective tissue, and vasculature. However, both OOCs and bioprinting so far demand a high degree of manual intervention, thereby impeding efficiency and inhibiting scalability to meet technological requirements. Through the combination of drop-on-demand bioprinting with robotic handling of microfluidic chips, a print procedure is achieved that is proficient in managing three distinct tissue models on a chip within only a minute, as well

SUBMITTER: Fritschen A 

PROVIDER: S-EPMC11469029 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature