Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue.

ABSTRACT: Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here, a tissue-specific hybrid bioink is described, composed of a natural polymer, alginate, reinforced with extracellular matrix derived from decellularized tissue (rECM). rECM has rheological and gelation properties beneficial for 3D bioprinting while retaining biologically inductive properties supporting tissue maturation ex vivo and in vivo. These bioinks are shear thinning, resist cell sedimentation, improve viability of multiple cell types, and enhance mechanical stability in hydrogels derived from them. 3D printed constructs generated from rECM bioinks sup

SUBMITTER: De Santis MM 

PROVIDER: S-EPMC11469085 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature