Intracellular Dynamic Assembly of Deep-Red Emitting Supramolecular Nanostructures Based on the Pt…Pt Metallophilic Interaction.

ABSTRACT: Many drug delivery systems end up in the lysosome because they are built from covalent or kinetically inert supramolecular bonds. To reach other organelles, nanoparticles hence need to either be made from a kinetically labile interaction that allows re-assembly of the nanoparticles inside the cell following endocytic uptake, or, be taken up by a mechanism that short-circuits the classical endocytosis pathway. In this work, the intracellular fate of nanorods that self-assemble via the Pt…Pt interaction of cyclometalated platinum(II) compounds, is studied. These deep-red emissive nanostructures (638 nm excitation, ≈700 nm emission) are stabilized by proteins in cell medium. Once in contact with cancer cells, they cross the cell membrane via dynamin- and clathrin-dependent endocytosis. Howeve

SUBMITTER: Zhou XQ 

PROVIDER: S-EPMC11469088 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature